Lefamulin’s mechanism of action has a low inclination for developing resistance. The drug is a member of the pleuromutilin antibiotic class, and it has low propensity for cross resistance with a variety of antibiotic classes such as macrolide and tetracycline.
Each year, doctors in the U.S. perform more than 4 billion diagnostic tests, which have become more sophisticated and easier to execute as technology has improved. However, research has found that many physicians assume tests are more accurate than they are.
Jen, who has been fighting Cystic Fibrosis her whole life, is not a typical healthy adult and this bout with the “common cold” quickly escalated and culminated with Jen being fast-tracked for a double lung transplant. She had watched her lung function decrease over the years sometimes slowly, other times having a rapid decline. This was a rapid decline and the straw that broke the camel’s back.
PCT has become the workhorse diagnostic test for many antibiotic stewardship programs in the U.S. and abroad. The latest issue of the Cleveland Clinic Journal of Medicine (CCJM) highlights the important role PCT testing now plays in stewardship.